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The prevalence of ANA rose between 1988 and 2012, but this upward trend was not linear, showing a relatively small increase from 19881991 to 1999-2004, followed by a much larger increase from 19992004 to 2011-2012

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Manufacture and production The processes involved in manufacturing cigarettes alone can cause the most environmental damage during tobaccos life cycle because of the large amounts of energy, water and other resources used

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